{"id":2467,"date":"2025-04-19T08:08:22","date_gmt":"2025-04-18T23:08:22","guid":{"rendered":"https:\/\/www.kanshoho.com\/jp\/?page_id=2467"},"modified":"2025-05-06T09:41:36","modified_gmt":"2025-05-06T00:41:36","slug":"hypothesis","status":"publish","type":"page","link":"https:\/\/www.kanshoho.com\/jp\/hypothesis\/","title":{"rendered":"\u7d44\u7e54\u30ec\u30d9\u30eb\u4eee\u8aac"},"content":{"rendered":"<h5>\u7de9\u6d88\u6cd5\u306e\u7d44\u7e54\u30ec\u30d9\u30eb\u3067\u306e\u4f5c\u7528\u306b\u95a2\u3059\u308b\u591a\u89d2\u7684\u4eee\u8aac<\/h5>\n<h2>\u305f\u3060\u3044\u307e\u88fd\u4f5c\u4e2d\u3067\u3059\u3002<\/h2>\n<p>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"300\" height=\"225\" src=\"https:\/\/www.kanshoho.com\/jp\/wp-content\/uploads\/2023\/11\/1494766-300x225.png\" alt=\"\" srcset=\"https:\/\/www.kanshoho.com\/jp\/wp-content\/uploads\/2023\/11\/1494766-300x225.png 300w, 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data-end=\"116\">\u758e\u6027\u7d50\u5408\u7d44\u7e54\u5c64<\/strong>\u306b\u5b58\u5728\u3059\u308b\u30d2\u30a2\u30eb\u30ed\u30f3\u9178(HA)\u306b\u305b\u3093\u65ad\u529b\u3092\u4e0e\u3048\u3001\u305d\u306e<strong data-start=\"142\" data-end=\"153\">\u975e\u30cb\u30e5\u30fc\u30c8\u30f3\u6027<\/strong>\uff08\u526a\u65ad\u901f\u5ea6\u4f9d\u5b58\u306e\u7c98\u6027\uff09\u306b\u3088\u308a\u7c98\u5ea6\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3068\u8003\u3048\u3089\u308c\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9569978\/#:~:text=Obesity%20is%20associated%20with%20diminished,to%20a%20more%20viscous%20state\" target=\"_blank\" rel=\"noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u5b9f\u969b\u3001<strong data-start=\"229\" data-end=\"251\">\u529b\u5b66\u7684\u8377\u91cd\u304c\u52a0\u308f\u308b\u3068HA\u306e\u7c98\u5ea6\u304c\u4f4e\u4e0b<\/strong>\u3057\u3001\u9759\u6b62\u72b6\u614b\u3067\u518d\u3073\u7c98\u5ea6\u304c\u4e0a\u304c\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9569978\/#:~:text=Obesity%20is%20associated%20with%20diminished,to%20a%20more%20viscous%20state\" target=\"_blank\" rel=\"noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u3053\u306e\u7c98\u5ea6\u4f4e\u4e0b\u306f\u7b4b\u819c\u5c64\u9593\u306e\u6f64\u6ed1\u6027\u3092\u9ad8\u3081\u3001\u300c<strong data-start=\"341\" data-end=\"354\">\u30d5\u30a1\u30b7\u30a2\u306e\u6ed1\u8d70\u969c\u5bb3<\/strong>\u300d\u3092\u6539\u5584\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002Roman\u3089\u306e\u7814\u7a76\u306b\u3088\u308c\u3070\u3001\u624b\u6280\u306b\u3088\u308b\u7b4b\u819c\u3078\u306e\u52d5\u7684\u523a\u6fc0\u3067<strong data-start=\"395\" data-end=\"421\">\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u306e\u6d41\u52d5\u6027\u304c\u9ad8\u307e\u308a\u7c98\u5f3e\u6027\u7279\u6027\u304c\u6539\u5584<\/strong>\u3055\u308c\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b<a href=\"https:\/\/bmccomplementmedtherapies.biomedcentral.com\/articles\/10.1186\/s12906-024-04687-9#:~:text=single%20PT%20session%20immediately%20improved,in%20fascial%20thickness%20were%20observed\" target=\"_blank\" rel=\"noopener\">bmccomplementmedtherapies.biomedcentral.com<\/a>\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u7b4b\u819c\u306e\u300c<strong data-start=\"489\" data-end=\"523\">\u6fc3\u7e2e\u5316\uff08\u30c7\u30f3\u30b7\u30d5\u30a3\u30b1\u30fc\u30b7\u30e7\u30f3\uff09\u203bHA\u904e\u5270\u51dd\u96c6\u306b\u3088\u308b\u53ef\u52d5\u6027\u4f4e\u4e0b<\/strong>\u300d\u304c\u89e3\u6d88\u3057\u3001\u7b4b\u819c\u306e\u6ed1\u308a\u3068\u53ef\u52d5\u57df\u304c\u901f\u3084\u304b\u306b\u6539\u5584\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/p>\n<p data-start=\"556\" data-end=\"572\"><strong data-start=\"556\" data-end=\"570\">\u53c2\u8003\u6587\u732e\uff08\u4eee\u8aac1\uff09:<\/strong><\/p>\n<ul data-start=\"573\" data-end=\"1000\">\n<li data-start=\"573\" data-end=\"809\">\n<p data-start=\"575\" data-end=\"809\"><em data-start=\"575\" data-end=\"674\">Mathematical analysis of the flow of hyaluronic acid around fascia during manual therapy motions.<\/em> Roman M, Chaudhry H, Bukiet B, Stecco A, Findley TW. 2013, J Am Osteopath Assoc. PubMed<\/p>\n<\/li>\n<li data-start=\"810\" data-end=\"1000\">\n<p data-start=\"812\" data-end=\"1000\"><em data-start=\"812\" data-end=\"880\">Viscoelastic Properties of Hyaluronan in Physiological Conditions.<\/em> Cowman MK, Schmidt TA, Raghavan P, Stecco A. 2015, F1000Research. PubMed<\/p>\n<\/li>\n<\/ul>\n<h2 data-start=\"1002\" data-end=\"1039\">\u4eee\u8aac2\uff1a\u7b4b\u819c\u69cb\u9020\u306e\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\uff08\u30b3\u30e9\u30fc\u30b2\u30f3\u7dda\u7dad\u914d\u5411\u3068\u7652\u7740\u306e\u89e3\u6d88\uff09<\/h2>\n<p data-start=\"1040\" data-end=\"1589\"><strong data-start=\"1040\" data-end=\"1047\">\u5185\u5bb9\uff1a<\/strong> \u624b\u6280\u306b\u3088\u308b\u6301\u7d9a\u5727\u3068\u6a2a\u65b9\u5411\u306e\u6469\u64e6\u523a\u6fc0\u306f\u3001\u7b4b\u819c\u4e2d\u306e<strong data-start=\"1071\" data-end=\"1083\">\u30b3\u30e9\u30fc\u30b2\u30f3\u7dda\u7dad\u7db2<\/strong>\u306b\u5fae\u7d30\u306a\u5909\u5f62\u3092\u4e0e\u3048\u3001\u51dd\u96c6\u3057\u305f\u7dda\u7dad\u306e\u914d\u5217\u3092\u518d\u7de8\u6210\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u3053\u308c\u306f\u3001<strong data-start=\"1119\" data-end=\"1285\">\u30b3\u30e9\u30fc\u30b2\u30f3\u7e4a\u7dad\u9593\u306e\u7d50\u5408\uff08\u4f8b\uff1a\u6c34\u7d20\u7d50\u5408\u3084\u8de8\u304e\u9023\u7d50\uff09\u3092\u65ad\u88c2\u30fb\u6ed1\u8d70\u3055\u305b\u3001\u7652\u7740\u3092\u89e3\u653e\u3059\u308b\u3053\u3068\u3067\u7b4b\u819c\u306e\u67d4\u8edf\u6027\u304c\u5897\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u200b<a href=\"https:\/\/www.physio.co.uk\/treatments\/massage\/physiological-effects-of-massage\/mechanical-effects\/breakdown-realignment-of-collagen-fibres.php#:~:text=Breakdown%20Realignment%20Of%20Collagen%20Fibres,and%20increase%20range%20of%20movement\" target=\"_blank\" rel=\"noopener\">physio.co.uk<\/a>\u3002\u30de\u30c3\u30b5\u30fc\u30b8\u306b\u3088\u308b\u6a5f\u68b0\u7684\u5727\u529b\u306f\u7b4b\u7d44\u7e54\u30fb\u7b4b\u819c\u306e\u30b3\u30f3\u30d7\u30e9\u30a4\u30a2\u30f3\u30b9\uff08\u9806\u5fdc\u6027\uff09\u3092\u9ad8\u3081\u3001\u95a2\u7bc0\u53ef\u52d5\u57df\u306e\u5897\u5927\u30fb\u53d7\u52d5\u7684\u525b\u6027\u306e\u4f4e\u4e0b<\/strong>\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u200b<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15730338\/#:~:text=Many%20coaches%2C%20athletes%20and%20sports,on%20the%20massage%20technique%2C%20mechanical\" target=\"_blank\" rel=\"noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u3002\u3053\u308c\u306f\u7b4b\u819c\u30fb\u7b4b\u306e\u5fae\u7d30\u69cb\u9020\u306b\u5909\u5316\u304c\u751f\u3058\u305f\u7d50\u679c\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u307e\u305f\u3001<strong data-start=\"1376\" data-end=\"1397\">\u4fee\u5fa9\u904e\u7a0b\u521d\u671f\u306b\u304a\u3051\u308b\u6a2a\u65b9\u5411\u6469\u64e6\u523a\u6fc0<\/strong>\u306f\u7622\u75d5\u7d44\u7e54\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u7dda\u7dad\u3092\u7e26\u65b9\u5411\u306b\u518d\u914d\u5411\u3055\u305b\u308b\u3068\u306e\u5831\u544a\u3082\u3042\u308a\u200b<a href=\"https:\/\/www.physio-pedia.com\/Deep_Friction_Massage#:~:text=Deep%20Friction%20Massage%20,Prevention\" target=\"_blank\" rel=\"noopener\">physio-pedia.com<\/a>\u3001\u9069\u5207\u306a\u5727\u523a\u6fc0\u304c\u7b4b\u819c\u7dda\u7dad\u306e\u5065\u5168\u306a\u914d\u5217\u3092\u4fc3\u9032\u3057\u3001<strong data-start=\"1495\" data-end=\"1514\">\u7b4b\u786c\u7d50\u3084\u7622\u75d5\u306e\u7d44\u7e54\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0<\/strong>\u3092\u4fc3\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u4ee5\u4e0a\u304b\u3089\u3001\u7de9\u6d88\u6cd5\u306e\u6a5f\u68b0\u523a\u6fc0\u306f\u7b4b\u819c\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u306b\u7269\u7406\u7684\u5909\u5316\u3092\u4e0e\u3048\u3001<strong data-start=\"1562\" data-end=\"1577\">\u7b4b\u819c\u306e\u5f3e\u6027\u30fb\u67d4\u8edf\u6027\u5411\u4e0a<\/strong>\u306b\u3064\u306a\u304c\u308b\u3068\u63a8\u5bdf\u3055\u308c\u308b\u3002<\/p>\n<p data-start=\"1591\" data-end=\"1607\"><strong data-start=\"1591\" data-end=\"1605\">\u53c2\u8003\u6587\u732e\uff08\u4eee\u8aac2\uff09:<\/strong><\/p>\n<ul data-start=\"1608\" data-end=\"1807\">\n<li data-start=\"1608\" data-end=\"1807\">\n<p data-start=\"1610\" data-end=\"1807\"><em data-start=\"1610\" data-end=\"1704\">The mechanisms of massage and effects on performance, muscle recovery and injury prevention.<\/em> Weerapong P, Hume PA, Kolt GS. 2005, Sports Med. PubMed<\/p>\n<\/li>\n<\/ul>\n<h2 data-start=\"1809\" data-end=\"1837\">\u4eee\u8aac3\uff1a\u7d44\u7e54\u6db2\u306e\u5727\u51fa\u30fb\u518d\u5438\u53ce\u3068\u30ea\u30f3\u30d1\u5faa\u74b0\u306e\u4fc3\u9032<\/h2>\n<p data-start=\"1838\" data-end=\"2442\"><strong data-start=\"1838\" data-end=\"1845\">\u5185\u5bb9\uff1a<\/strong> \u7de9\u6d88\u6cd5\u3067\u52a0\u3048\u3089\u308c\u308b\u5468\u671f\u7684\u5727\u8feb\uff08\u7d040.5kgf\uff09\u3068\u7de9\u89e3\u306f\u3001\u7d44\u7e54\u5185\u306e<strong data-start=\"1878\" data-end=\"1994\">\u9593\u8cea\u6db2\uff08\u7d44\u7e54\u6db2\uff09\u306b\u30dd\u30f3\u30d7\u4f5c\u7528\u3092\u53ca\u307c\u3059\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u5727\u529b\u304c\u52a0\u308f\u308b\u5c40\u9762\u3067\u306f\u3001\u5c40\u6240\u7d44\u7e54\u304b\u3089\u4f59\u5270\u306a\u6c34\u5206\u304c\u7d5e\u308a\u51fa\u3055\u308c\u3066\u6bdb\u7d30\u8840\u7ba1\u3084\u30ea\u30f3\u30d1\u7ba1\u3078\u3068\u62bc\u3057\u51fa\u3055\u308c\u3001\u5727\u529b\u3092\u7de9\u3081\u308b\u5c40\u9762\u3067\u306f\u65b0\u9bae\u306a\u6db2\u4f53\u304c\u7d44\u7e54\u306b\u518d\u704c\u6d41\u3059\u308b\u3002\u3053\u306e\u5727\u8feb\u3068\u89e3\u653e\u306e\u7e70\u308a\u8fd4\u3057<\/strong>\u306b\u3088\u308a\u9593\u8cea\u6db2\u306e\u4ea4\u63db\u304c\u6d3b\u6027\u5316\u3057\u3001<strong data-start=\"2009\" data-end=\"2018\">\u6d6e\u816b\u306e\u8efd\u6e1b<\/strong>\u3084<strong data-start=\"2019\" data-end=\"2029\">\u8001\u5ec3\u7269\u306e\u6392\u51fa<\/strong>\u304c\u4fc3\u9032\u3055\u308c\u308b\u200b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2755111\/#:~:text=body%20fluid%20dynamics%2C%20thereby%20facilitating,dynamics%20in%20treating%20ill%20or\" target=\"_blank\" rel=\"noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u5b9f\u969b\u3001\u30de\u30cb\u30e5\u30a2\u30eb\u30bb\u30e9\u30d4\u30fc\u306e\u4e00\u7a2e\u3067\u3042\u308b<strong data-start=\"2098\" data-end=\"2107\">\u865a\u8840\u5727\u8feb\u6cd5<\/strong>\u3067\u306f\u3001\u5727\u8feb\u306b\u3088\u3063\u3066\u5c40\u6240\u306e\u865a\u8840\u30fb\u4f4e\u9178\u7d20\u72b6\u614b\u3092\u4e00\u6642\u7684\u306b\u4f5c\u308a\u3001\u89e3\u653e\u6642\u306b\u8840\u6d41\u3092\u518d\u958b\u3055\u305b\u308b\u3053\u3068\u3067<strong data-start=\"2150\" data-end=\"2165\">\u708e\u75c7\u6027\u7269\u8cea\u306e\u6ede\u7559\u3092\u6e1b\u5c11<\/strong>\u3055\u305b\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3092\u8abf\u6574\u3059\u308b\u3068\u3044\u3063\u305f\u4f5c\u7528\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u308b\u200b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9434898\/#:~:text=,53%5D.%20This%20may%20be\" target=\"_blank\" rel=\"noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u3055\u3089\u306b\u3001\u624b\u6280\u7642\u6cd5\u5168\u822c\u306b\u304a\u3044\u3066<strong data-start=\"2251\" data-end=\"2265\">\u30ea\u30f3\u30d1\u6db2\u306e\u6d41\u52d5\u6027\u5411\u4e0a<\/strong>\u304c\u89b3\u5bdf\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u308c\u304c<strong data-start=\"2277\" data-end=\"2286\">\u6d6e\u816b\u306e\u6e1b\u5c11<\/strong>\u3084<strong data-start=\"2287\" data-end=\"2300\">\u7d44\u7e54\u306e\u6392\u6cc4\u6a5f\u80fd\u5411\u4e0a<\/strong>\u306b\u3064\u306a\u304c\u308b\u3068\u306e\u5831\u544a\u3082\u3042\u308b\u200b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2755111\/#:~:text=body%20fluid%20dynamics%2C%20thereby%20facilitating,dynamics%20in%20treating%20ill%20or\" target=\"_blank\" rel=\"noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u4ee5\u4e0a\u3088\u308a\u3001\u7de9\u6d88\u6cd5\u306e\u30ea\u30ba\u30df\u30ab\u30eb\u306a\u5727\u523a\u6fc0\u306f<strong data-start=\"2376\" data-end=\"2390\">\u9593\u8cea\u6db2\u306e\u529b\u5b66\u7684\u306a\u52d5\u54e1<\/strong>\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u5c40\u6240\u306e\u6c34\u5206\u30d0\u30e9\u30f3\u30b9\u3092\u6574\u3048\u308b\u3068\u3068\u3082\u306b\u30ea\u30f3\u30d1\u5faa\u74b0\u3092\u4ecb\u3057\u305f\u4ee3\u8b1d\u7523\u7269\u306e\u9664\u53bb\u3092\u4fc3\u9032\u3059\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3002<\/p>\n<p data-start=\"2444\" data-end=\"2460\"><strong data-start=\"2444\" data-end=\"2458\">\u53c2\u8003\u6587\u732e\uff08\u4eee\u8aac3\uff09:<\/strong><\/p>\n<ul data-start=\"2461\" data-end=\"2669\">\n<li data-start=\"2461\" data-end=\"2669\">\n<p data-start=\"2463\" data-end=\"2669\"><em data-start=\"2463\" data-end=\"2563\">Effect of ischemic compression on myofascial pain syndrome: a systematic review and meta-analysis.<\/em> Lu W, Li J, Tian Y, Lu X. 2022, Chiropr Man Therap. PubMed<\/p>\n<\/li>\n<\/ul>\n<h2 data-start=\"2671\" data-end=\"2704\">\u4eee\u8aac4\uff1a\u30a4\u30aa\u30f3\u30d0\u30e9\u30f3\u30b9\u306e\u6b63\u5e38\u5316\uff08pH\u30fb\u96fb\u89e3\u8cea\u74b0\u5883\u306e\u6539\u5584\uff09<\/h2>\n<p data-start=\"2705\" data-end=\"3442\"><strong data-start=\"2705\" data-end=\"2712\">\u5185\u5bb9\uff1a<\/strong> \u7b4b\u30fb\u7b4b\u819c\u7d44\u7e54\u3078\u306e\u5727\u523a\u6fc0\u306f\u3001\u5c40\u6240\u306e<strong data-start=\"2729\" data-end=\"2738\">\u30a4\u30aa\u30f3\u74b0\u5883<\/strong>\u306b\u3082\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u5f37\u3044\u6301\u7d9a\u5727\u306f\u4e00\u904e\u6027\u306b\u5fae\u5c0f\u5faa\u74b0\u3092\u5727\u8feb\u3057\u5c40\u6240\u7684\u306a\u9178\u7d20\u4e0d\u8db3\u3092\u62db\u304d\u307e\u3059\u304c\u3001\u5727\u3092\u629c\u304f\u3068<strong data-start=\"2791\" data-end=\"3007\">\u53cd\u52d5\u7684\u306a\u8840\u6d41\u518d\u958b\uff08Reactive Hyperemia\uff09\u304c\u751f\u3058\u3001\u3053\u308c\u306b\u3088\u308a\u7d44\u7e54\u5185\u306b\u84c4\u7a4d\u3057\u305f\u6c34\u7d20\u30a4\u30aa\u30f3\uff08H\u207a\uff09\u3084\u30ab\u30ea\u30a6\u30e0\u30a4\u30aa\u30f3\uff08K\u207a\uff09\u306a\u3069\u75b2\u52b4\u7269\u8cea\u304c\u6d17\u3044\u6d41\u3055\u308c\u308b\u200b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9434898\/#:~:text=,53%5D.%20This%20may%20be\" target=\"_blank\" rel=\"noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u7d50\u679c\u3068\u3057\u3066\u7d44\u7e54pH\u304c\u662f\u6b63\u3055\u308c\u3001\u7b4b\u75b2\u52b4\u306b\u4f34\u3046\u5c40\u6240\u306e\u9178\u6027\u5316\u304c\u6539\u5584\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u307e\u305f\u3001\u7b4b\u819c\u3084\u7b4b\u7e4a\u7dad\u306e\u7d30\u80de\u819c\u4e0a\u306b\u306f\u6a5f\u68b0\u523a\u6fc0\u306b\u53cd\u5fdc\u3059\u308b\u6a5f\u68b0\u611f\u53d7\u6027\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb<\/strong>\uff08\u4f8b\uff1aPiezo2\u3001TRPV\u578b\u30c1\u30e3\u30cd\u30eb\u306a\u3069\uff09\u304c\u5b58\u5728\u3057\u3001\u5727\u523a\u6fc0\u306b\u3088\u308a\u4e00\u6642\u7684\u306a\u30a4\u30aa\u30f3\u6d41\u5165\uff08\u4e3b\u306bCa\u00b2\u207a\uff09\u304c\u8d77\u3053\u308b\u200b<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23460361\/#:~:text=Fibroblasts%20in%20whole%20areolar%20connective,and\" target=\"_blank\" rel=\"noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u3002\u3053\u306eCa\u00b2\u207a\u30b7\u30b0\u30ca\u30eb\u306f\u7d30\u80de\u5185\u306e\u4ee3\u8b1d\u9175\u7d20\u6d3b\u6027\u3092\u5909\u5316\u3055\u305b\u305f\u308a\u3001\u5e73\u6ed1\u7b4b\u306e\u5f1b\u7de9\u56e0\u5b50\u3067\u3042\u308b\u4e00\u9178\u5316\u7a92\u7d20(NO)\u306e\u653e\u51fa\u3092\u4fc3\u3057\u8840\u7ba1\u62e1\u5f35\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u4e8b\u5b9f\u3001\u9069\u5ea6\u306a\u529b\u5b66\u523a\u6fc0\u306f<strong data-start=\"3190\" data-end=\"3215\">\u5c40\u6240\u306e\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3084\u708e\u75c7\u6027\u7269\u8cea\u306e\u84c4\u7a4d\u3092\u8efd\u6e1b<\/strong>\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u200b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9434898\/#:~:text=,53%5D.%20This%20may%20be\" target=\"_blank\" rel=\"noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3001\u3053\u308c\u306f\u30a4\u30aa\u30f3\u74b0\u5883\u306e\u6052\u5e38\u6027\u7dad\u6301\u306b\u3082\u5bc4\u4e0e\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u3055\u3089\u306b\u3001\u3053\u3046\u3057\u305f\u30a4\u30aa\u30f3\u30d0\u30e9\u30f3\u30b9\u306e\u6539\u5584\u306f\u7b4b\u7d21\u9318\u3084\u30b4\u30eb\u30b8\u8171\u5668\u5b98\u306e\u611f\u53d7\u6027\u306b\u3082\u5f71\u97ff\u3057\u3001\u904e\u5270\u306a\u7b4b\u7dca\u5f35\u306e\u7de9\u548c\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\uff08\u7b4b\u30b9\u30d4\u30f3\u30c9\u30eb\u306e\u6c42\u5fc3\u6027\u767a\u706b\u983b\u5ea6\u4f4e\u4e0b\u306a\u3069\uff09\u3002\u4ee5\u4e0a\u3088\u308a\u3001\u7de9\u6d88\u6cd5\u306b\u3088\u308b\u523a\u6fc0\u306f<strong data-start=\"3395\" data-end=\"3414\">\u5c40\u6240\u306e\u30a4\u30aa\u30f3\u30fbpH\u74b0\u5883\u3092\u6b63\u5e38\u5316<\/strong>\u3057\u3001\u7b4b\u30fb\u7b4b\u819c\u306e\u8208\u596e\u6027\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u50cd\u304d\u304c\u3042\u308b\u3068\u63a8\u5bdf\u3055\u308c\u308b\u3002<\/p>\n<p data-start=\"3444\" data-end=\"3460\"><strong data-start=\"3444\" data-end=\"3458\">\u53c2\u8003\u6587\u732e\uff08\u4eee\u8aac4\uff09:<\/strong><\/p>\n<ul data-start=\"3461\" data-end=\"3669\">\n<li data-start=\"3461\" data-end=\"3669\">\n<p data-start=\"3463\" data-end=\"3669\"><em data-start=\"3463\" data-end=\"3563\">Effect of ischemic compression on myofascial pain syndrome: a systematic review and meta-analysis.<\/em> Lu W, Li J, Tian Y, Lu X. 2022, Chiropr Man Therap. PubMed<\/p>\n<\/li>\n<\/ul>\n<h2 data-start=\"3671\" data-end=\"3708\">\u4eee\u8aac5\uff1a\u30e1\u30ab\u30ce\u30c8\u30e9\u30f3\u30b9\u30c0\u30af\u30b7\u30e7\u30f3\u306b\u3088\u308b\u7d30\u80de\u5fdc\u7b54\u3068\u7d44\u7e54\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0<\/h2>\n<p data-start=\"3709\" data-end=\"4594\"><strong data-start=\"3709\" data-end=\"3716\">\u5185\u5bb9\uff1a<\/strong> \u7b4b\u819c\u30fb\u7b4b\u7d44\u7e54\u306b\u306f\u3001\u6a5f\u68b0\u7684\u523a\u6fc0\u3092<strong data-start=\"3732\" data-end=\"3743\">\u751f\u5316\u5b66\u30b7\u30b0\u30ca\u30eb<\/strong>\u306b\u5909\u63db\u3059\u308b\u4ed5\u7d44\u307f\uff08\u30e1\u30ab\u30ce\u30c8\u30e9\u30f3\u30b9\u30c0\u30af\u30b7\u30e7\u30f3\uff09\u304c\u5099\u308f\u3063\u3066\u3044\u308b\u3002\u7de9\u6d88\u6cd5\u3067\u52a0\u308f\u308b\u5727\u529b\u30fb\u305b\u3093\u65ad\u523a\u6fc0\u306b\u3088\u308a\u3001\u7b4b\u819c\u5185\u306e<strong data-start=\"3796\" data-end=\"4062\">\u7dda\u7dad\u82bd\u7d30\u80de\uff08\u7b4b\u819c\u7d30\u80de\uff09\u304c\u6a5f\u68b0\u523a\u6fc0\u3092\u611f\u77e5\u3057\u3001\u7d30\u80de\u5f62\u614b\u3084\u5206\u6ccc\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u5909\u5316\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002Langevin\u3089\u306e\u7814\u7a76\u3067\u306f\u3001\u7d50\u5408\u7d44\u7e54\u306b\u6301\u7d9a\u7684\u306a\u727d\u5f15\u523a\u6fc0\u3092\u52a0\u3048\u308b\u3068\u7dda\u7dad\u82bd\u7d30\u80de\u304c\u6570\u5206\u4ee5\u5185\u306b\u5f62\u614b\u5909\u5316\uff08\u7d30\u80de\u4f53\u306e\u5c55\u958b\u3084\u9aa8\u683c\u518d\u69cb\u7bc9\uff09\u3092\u8d77\u3053\u3059\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u200b<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16416024\/#:~:text=Mechanical%20stretching%20of%20connective%20tissue,smooth%20muscle\" target=\"_blank\" rel=\"noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u3002\u3055\u3089\u306b\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\u3001\u4f38\u5c55\u523a\u6fc0\u306b\u5fdc\u7b54\u3057\u3066\u7d30\u80de\u5916ATP\u304c\u653e\u51fa\u3055\u308c\u3001\u305d\u308c\u304c\u30aa\u30fc\u30c8\u30af\u30ea\u30f3\/\u30d1\u30e9\u30af\u30ea\u30f3\u306b\u7d30\u80de\u819c\u4e0a\u306e\u30d7\u30ea\u30f3\u53d7\u5bb9\u4f53\u3092\u523a\u6fc0\u3057\u3001\u7dda\u7dad\u82bd\u7d30\u80de\u306e\u30a2\u30af\u30c1\u30f3\u9aa8\u683c\u304c\u518d\u7de8\u6210<\/strong>\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u3066\u3044\u308b\u200b<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23460361\/#:~:text=Fibroblasts%20in%20whole%20areolar%20connective,and\" target=\"_blank\" rel=\"noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u3002\u3053\u306e\u3088\u3046\u306b\u6a5f\u68b0\u523a\u6fc0\u306f\u7d30\u80de\u5185\u3067<strong data-start=\"4138\" data-end=\"4162\">Ca\u00b2\u207a\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3084Rho\u30ad\u30ca\u30fc\u30bc\u7d4c\u8def<\/strong>\u3092\u6d3b\u6027\u5316\u3057\u3001\u7dda\u7dad\u82bd\u7d30\u80de\u3084\u7b4b\u7d30\u80de\u306b<strong data-start=\"4178\" data-end=\"4199\">\u30b3\u30e9\u30fc\u30b2\u30f3\u3084\u30d7\u30ed\u30c6\u30a2\u30fc\u30bc\u306e\u7523\u751f\u8abf\u7bc0<\/strong>\u3092\u5f15\u304d\u8d77\u3053\u3059\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u307e\u305f\u3001\u7b4b\u7dda\u7dad\u306b\u304a\u3044\u3066\u3082\u819c\u306e\u30a4\u30f3\u30c6\u30b0\u30ea\u30f3\u3084\u30b3\u30b9\u30c8\u30de\u30fc\u304c\u6a5f\u68b0\u523a\u6fc0\u3092\u611f\u53d7\u3057\u3001FAK\u3084MAP\u30ad\u30ca\u30fc\u30bc\u7d4c\u8def\uff08ERK1\/2\uff09\u306e\u6d3b\u6027\u5316\u3092\u4ecb\u3057\u3066<strong data-start=\"4276\" data-end=\"4285\">\u907a\u4f1d\u5b50\u767a\u73fe<\/strong>\u304c\u5909\u5316\u3059\u308b\u200b<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22301554\/#:~:text=found%20that%20massage%20activated%20the,to%20skeletal%20muscle%20that%20has\" target=\"_blank\" rel=\"noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u3002\u4f8b\u3048\u3070\u30de\u30c3\u30b5\u30fc\u30b8\u523a\u6fc0\u306b\u3088\u308a\u3001\u708e\u75c7\u3084\u7b4b\u80a5\u5927\u306b\u95a2\u4e0e\u3059\u308bNF-\u03baB\u7d4c\u8def\u304c\u6291\u5236\u3055\u308c\u308b\u4e00\u65b9\u3001\u7b4b\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u3084\u518d\u751f\u306b\u95a2\u4e0e\u3059\u308b\u56e0\u5b50\u306e\u767a\u73fe\u304c\u5909\u5316\u3057\u305f\u3068\u306e\u5831\u544a\u304c\u3042\u308b\u200b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4393190\/#:~:text=2013%20%29,early%20phase%20might%20be%20related\" target=\"_blank\" rel=\"noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u4ee5\u4e0a\u3092\u7dcf\u5408\u3059\u308b\u3068\u3001\u7de9\u6d88\u6cd5\u306e\u7269\u7406\u523a\u6fc0\u306f\u7d30\u80de\u30ec\u30d9\u30eb\u3067<strong data-start=\"4482\" data-end=\"4522\">\u6a5f\u68b0\u53d7\u5bb9\u5668\u306e\u523a\u6fc0 \u2192 \u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u6d3b\u6027\u5316 \u2192 \u7d30\u80de\u306e\u5f62\u614b\u30fb\u6a5f\u80fd\u5909\u5316<\/strong>\u3068\u3044\u3046\u4e00\u9023\u306e\u5fdc\u7b54\uff08\u30e1\u30ab\u30ce\u30c8\u30e9\u30f3\u30b9\u30c0\u30af\u30b7\u30e7\u30f3\uff09\u3092\u8a98\u5c0e\u3057\u3001\u305d\u306e\u7d50\u679c\u3068\u3057\u3066\u7b4b\u30fb\u7b4b\u819c\u7d44\u7e54\u306e\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\uff08\u67d4\u8edf\u6027\u5411\u4e0a\u3084\u708e\u75c7\u6291\u5236\uff09\u304c\u4fc3\u9032\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/p>\n<p data-start=\"4596\" data-end=\"4612\"><strong data-start=\"4596\" data-end=\"4610\">\u53c2\u8003\u6587\u732e\uff08\u4eee\u8aac5\uff09:<\/strong><\/p>\n<ul data-start=\"4613\" data-end=\"4860\">\n<li data-start=\"4613\" data-end=\"4860\">\n<p data-start=\"4615\" data-end=\"4860\"><em data-start=\"4615\" data-end=\"4701\">Fibroblast cytoskeletal remodeling induced by tissue stretch involves ATP signaling.<\/em> Langevin HM, Fujita T, Bouffard NA, Takano T, Koptiuch C, Badger GJ, Nedergaard M. 2013, J Cell Physiol. PubMed<\/p>\n<\/li>\n<\/ul>\n<h2 data-start=\"4862\" data-end=\"4893\">\u4eee\u8aac6\uff1a\u4ea4\u611f\u795e\u7d4c\u6291\u5236\u3068\u526f\u4ea4\u611f\u795e\u7d4c\u306e\u8ce6\u6d3b\u306b\u3088\u308b\u93ae\u9759\u52b9\u679c<\/h2>\n<p data-start=\"4894\" data-end=\"5764\"><strong data-start=\"4894\" data-end=\"4901\">\u5185\u5bb9\uff1a<\/strong> \u7de9\u6d88\u6cd5\u306b\u3088\u308b\u5fc3\u5730\u3088\u3044\u523a\u6fc0\u306f\u3001\u81ea\u5f8b\u795e\u7d4c\u7cfb\u306b\u304a\u3044\u3066<strong data-start=\"4925\" data-end=\"4950\">\u4ea4\u611f\u795e\u7d4c\u6d3b\u52d5\u3092\u6291\u5236\u3057\u526f\u4ea4\u611f\u795e\u7d4c\u6d3b\u52d5\u3092\u9ad8\u3081\u308b<\/strong>\u65b9\u5411\u306b\u4f5c\u7528\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u9069\u5ea6\u306a\u5727\u3092\u4f34\u3046\u30de\u30c3\u30b5\u30fc\u30b8\u523a\u6fc0\u3067\u306f\u3001\u5fc3\u62cd\u6570\u3084\u8840\u5727\u306e\u4f4e\u4e0b\u3001\u5fc3\u62cd\u5909\u52d5(HRV)\u306b\u304a\u3051\u308b\u9ad8\u5468\u6ce2\u6210\u5206(HF)\u306e\u5897\u5927\u304c\u4e00\u8cab\u3057\u3066\u89b3\u5bdf\u3055\u308c\u3066\u304a\u308a\u200b<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/15730338\/#:~:text=active%20stiffness%20%28biomechanical%20mechanisms%29,mood%20state%20also%20cause%20relaxation\" target=\"_blank\" rel=\"noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u200b<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19283590\/#:~:text=of%20heart%20rate%20variability%20and,decreased%20HF%20and%20increased%20LF%2FHF\" target=\"_blank\" rel=\"noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u3001\u3053\u308c\u306f<strong data-start=\"5124\" data-end=\"5143\">\u8ff7\u8d70\u795e\u7d4c\uff08\u526f\u4ea4\u611f\uff09\u30c8\u30fc\u30f3\u306e\u4ea2\u9032<\/strong>\u3068\u4ea4\u611f\u795e\u7d4c\u6d3b\u52d5\u306e\u76f8\u5bfe\u7684\u4f4e\u4e0b\u3092\u793a\u3059\u200b<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19283590\/#:~:text=of%20heart%20rate%20variability%20and,decreased%20HF%20and%20increased%20LF%2FHF\" target=\"_blank\" rel=\"noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u3002Diego\u3089\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13\u3067\u306f\u3001\u4e2d\u7a0b\u5ea6\u5727\u306e\u30de\u30c3\u30b5\u30fc\u30b8\u3092\u53d7\u3051\u305f\u7fa4\u3067<strong data-start=\"5239\" data-end=\"5263\">HF\u6210\u5206\u306e\u6709\u610f\u306a\u5897\u5927\u3068LF\/HF\u6bd4\u306e\u4f4e\u4e0b<\/strong>\uff08\u4ea4\u611f\u795e\u7d4c\u304b\u3089\u526f\u4ea4\u611f\u795e\u7d4c\u512a\u4f4d\u3078\u306e\u30b7\u30d5\u30c8\uff09\u304c\u8d77\u3053\u308a\u3001\u53cd\u5bfe\u306b\u6975\u3081\u3066\u8efd\u3044\u5727\u523a\u6fc0\u3067\u306f\u4ea4\u611f\u795e\u7d4c\u512a\u4f4d\u306e\u53cd\u5fdc\u304c\u793a\u3055\u308c\u305f\u200b<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/19283590\/#:~:text=of%20heart%20rate%20variability%20and,decreased%20HF%20and%20increased%20LF%2FHF\" target=\"_blank\" rel=\"noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u3002\u3053\u306e\u526f\u4ea4\u611f\u795e\u7d4c\u8ce6\u6d3b\u306b\u3088\u308a\u3001\u5168\u8eab\u7684\u306a<strong data-start=\"5379\" data-end=\"5393\">\u30ea\u30e9\u30af\u30bc\u30fc\u30b7\u30e7\u30f3\u53cd\u5fdc<\/strong>\u304c\u5f15\u304d\u51fa\u3055\u308c\u3001\u7b4b\u306e\u7dca\u5f35\u4f4e\u4e0b\u3084\u75db\u899a\u904e\u654f\u306e\u6291\u5236\uff08\u810a\u9ac4\u30ec\u30d9\u30eb\u3067\u306e\u53cd\u5c04\u6291\u5236\u306b\u3088\u308b\uff09\u306b\u3064\u306a\u304c\u308b\u200b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5467308\/#:~:text=Researchers%20have%20also%20quantified%20the,87\" target=\"_blank\" rel=\"noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u52a0\u3048\u3066\u3001\u526f\u4ea4\u611f\u795e\u7d4c\u306e\u6d3b\u6027\u5316\u306f\u5ef6\u9ac4\u306e\u8ff7\u8d70\u795e\u7d4c\u6838\u3092\u4ecb\u3057\u3066<strong data-start=\"5508\" data-end=\"5519\">\u4e0b\u884c\u6027\u306e\u93ae\u75db\u7cfb<\/strong>\u3092\u4fc3\u9032\u3057\u3001\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306e<strong data-start=\"5530\" data-end=\"5540\">\u93ae\u9759\u30fb\u5b89\u5fc3\u611f<\/strong>\u306b\u5bc4\u4e0e\u3059\u308b\u3002\u5b9f\u969b\u3001\u9069\u5ea6\u306a\u5727\u523a\u6fc0\u5f8c\u306e\u8133\u6d3b\u52d5\u3092fMRI\u3067\u898b\u308b\u3068\u3001\u60c5\u52d5\u3084\u30b9\u30c8\u30ec\u30b9\u8abf\u7bc0\u306b\u95a2\u4e0e\u3059\u308b\u6241\u6843\u4f53\u3084\u8996\u5e8a\u4e0b\u90e8\u306e\u8840\u6d41\u304c\u5897\u52a0\u3057\u200b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5467308\/#:~:text=Anatomical%20studies%20suggest%20that%20baroreceptors%2C,82%20And%20data%20from%20an\" target=\"_blank\" rel=\"noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3001\u3053\u308c\u306f\u30bf\u30c3\u30c1\u523a\u6fc0\u304c<strong data-start=\"5655\" data-end=\"5673\">\u4e2d\u67a2\u795e\u7d4c\u3092\u4ecb\u3057\u305f\u81ea\u5f8b\u795e\u7d4c\u8abf\u6574<\/strong>\u3092\u884c\u3046\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002\u4ee5\u4e0a\u3088\u308a\u3001\u7de9\u6d88\u6cd5\u306f<strong data-start=\"5695\" data-end=\"5710\">\u4ea4\u611f\u795e\u7d4c\u306e\u904e\u7dca\u5f35\u3092\u7de9\u548c<\/strong>\u3057\u3001\u526f\u4ea4\u611f\u795e\u7d4c\u512a\u4f4d\u306e\u72b6\u614b\u3078\u81ea\u5f8b\u795e\u7d4c\u30d0\u30e9\u30f3\u30b9\u3092\u6574\u3048\u308b\u3053\u3068\u3067\u3001\u5168\u8eab\u306e\u93ae\u9759\u52b9\u679c\u3068\u75db\u307f\u306e\u8efd\u6e1b\u306b\u5bc4\u4e0e\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/p>\n<p data-start=\"5766\" data-end=\"5782\"><strong data-start=\"5766\" data-end=\"5780\">\u53c2\u8003\u6587\u732e\uff08\u4eee\u8aac6\uff09:<\/strong><\/p>\n<ul data-start=\"5783\" data-end=\"5976\">\n<li data-start=\"5783\" data-end=\"5976\">\n<p data-start=\"5785\" data-end=\"5976\"><em data-start=\"5785\" data-end=\"5863\">Moderate pressure massage elicits a parasympathetic nervous system response.<\/em> Diego MA, Field T, Hernandez-Reif M. 2009, Int J Neurosci. PubMed<\/p>\n<\/li>\n<\/ul>\n<h2 data-start=\"5978\" data-end=\"6010\">\u4eee\u8aac7\uff1a\u5185\u5206\u6ccc\u7cfb\u306e\u8abf\u6574\uff08\u30db\u30eb\u30e2\u30f3\u30fb\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u5909\u52d5\uff09<\/h2>\n<p data-start=\"6011\" data-end=\"6933\"><strong data-start=\"6011\" data-end=\"6018\">\u5185\u5bb9\uff1a<\/strong> \u7de9\u6d88\u6cd5\u306b\u3088\u308b\u6df1\u3044\u30ea\u30e9\u30af\u30bc\u30fc\u30b7\u30e7\u30f3\u53cd\u5fdc\u306f\u3001\u30db\u30eb\u30e2\u30f3\u5206\u6ccc\u306b\u3082\u5909\u5316\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u4e00\u822c\u306b\u3001\u30ea\u30e9\u30af\u30bc\u30fc\u30b7\u30e7\u30f3\u6642\u306b\u306f<strong data-start=\"6076\" data-end=\"6088\">\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3<\/strong>\u3067\u3042\u308b\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u3084\u30ab\u30c6\u30b3\u30fc\u30eb\u30a2\u30df\u30f3\uff08\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u30fb\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\uff09\u306e\u5206\u6ccc\u304c\u4f4e\u4e0b\u3057\u3001<strong data-start=\"6131\" data-end=\"6146\">\u30bb\u30ed\u30c8\u30cb\u30f3\u3084\u30c9\u30fc\u30d1\u30df\u30f3<\/strong>\u3068\u3044\u3063\u305f\u6c17\u5206\u6539\u5584\u306b\u95a2\u4e0e\u3059\u308b\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u304c\u5897\u52a0\u3059\u308b\u50be\u5411\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u200b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5467308\/#:~:text=Cortisol%20levels%20that%20are%20often,have%20increased\" target=\"_blank\" rel=\"noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u5b9f\u969b\u3001\u9069\u5ea6\u306a\u5727\u523a\u6fc0\u306e\u30de\u30c3\u30b5\u30fc\u30b8\u65bd\u8853\u5f8c\u306b\u306f\u3001\u8840\u4e2d\u306e<strong data-start=\"6251\" data-end=\"6278\">\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u3068\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u6fc3\u5ea6\u304c\u6709\u610f\u306b\u4f4e\u4e0b<\/strong>\u3057\u3001\u540c\u6642\u306b<strong data-start=\"6283\" data-end=\"6307\">\u8133\u5185\u30bb\u30ed\u30c8\u30cb\u30f3\u304a\u3088\u3073\u30c9\u30fc\u30d1\u30df\u30f3\u6fc3\u5ea6\u306e\u4e0a\u6607<\/strong>\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3068\u306e\u5831\u544a\u304c\u3042\u308b\u200b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5467308\/#:~:text=Cortisol%20levels%20that%20are%20often,have%20increased\" target=\"_blank\" rel=\"noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u307e\u305f\u3001\u30de\u30c3\u30b5\u30fc\u30b8\u306f<strong data-start=\"6376\" data-end=\"6389\">\u4e0b\u5782\u4f53\u5f8c\u8449\u30db\u30eb\u30e2\u30f3<\/strong>\u306b\u3082\u5f71\u97ff\u3092\u4e0e\u3048\u3001Morhenn\u3089\u306e\u7814\u7a76\u3067\u306f10\u5206\u9593\u306e\u30de\u30c3\u30b5\u30fc\u30b8\u65bd\u8853\u5f8c\u306b<strong data-start=\"6424\" data-end=\"6451\">\u611b\u60c5\u30db\u30eb\u30e2\u30f3\u3068\u547c\u3070\u308c\u308b\u30aa\u30ad\u30b7\u30c8\u30b7\u30f3\u306e\u6709\u610f\u306a\u4e0a\u6607<\/strong>\u304a\u3088\u3073\u30b9\u30c8\u30ec\u30b9\u95a2\u9023\u30db\u30eb\u30e2\u30f3\u3067\u3042\u308bACTH\uff08\u526f\u814e\u76ae\u8cea\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\uff09\u306e\u6709\u610f\u306a\u4f4e\u4e0b\u304c\u89b3\u5bdf\u3055\u308c\u3066\u3044\u308b\u200b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5467308\/#:~:text=massage%20group%20and%20decreased%20for,the%20moderate%20pressure%20massage%20group\" target=\"_blank\" rel=\"noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u3053\u308c\u3089\u306e\u5909\u5316\u306f<strong data-start=\"6551\" data-end=\"6564\">\u30b9\u30c8\u30ec\u30b9\u53cd\u5fdc\u306e\u6291\u5236<\/strong>\u3068<strong data-start=\"6565\" data-end=\"6575\">\u60c5\u52d5\u306e\u5b89\u5b9a\u5316<\/strong>\u306b\u5bc4\u4e0e\u3057\u3001\u65bd\u8853\u5f8c\u306e\u30ea\u30e9\u30c3\u30af\u30b9\u611f\u3084\u7cbe\u795e\u7684\u5b89\u5b9a\u306b\u3064\u306a\u304c\u308b\u3002\u307e\u305f\u3001\u7de9\u6d88\u6cd5\u306e\u516c\u5f0f\u30b5\u30a4\u30c8\u3067\u5831\u544a\u3055\u308c\u305f\u30c7\u30fc\u30bf\u3067\u3082\u3001\u65bd\u8853\u5f8c\u306b\u8840\u4e2d<strong data-start=\"6632\" data-end=\"6647\">\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u306e\u4e0a\u6607<\/strong>\u3084<strong data-start=\"6648\" data-end=\"6660\">\u30bb\u30ed\u30c8\u30cb\u30f3\u306e\u4e0a\u6607<\/strong>\u304c\u8a8d\u3081\u3089\u308c\u3066\u304a\u308a\uff08\u5065\u5e38\u8005\u5bfe\u8c61\uff09\u200b<a href=\"https:\/\/www.kanshoho.com\/biochemistry-hormones-kanshohokanshoho-html\/#:~:text=,may%20contribute%20to%20improved%20concentration\" target=\"_blank\" rel=\"noopener\">kanshoho.com<\/a>\u3001\u3053\u308c\u306f\u77ed\u6642\u9593\u3067\u4e2d\u67a2\u795e\u7d4c\u7cfb\u306e<strong data-start=\"6735\" data-end=\"6746\">\u30e2\u30ce\u30a2\u30df\u30f3\u52d5\u614b<\/strong>\u304c\u5909\u5316\u3057\u3046\u308b\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u3002\u305f\u3060\u3057\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u4e0a\u6607\u306f\u4e00\u904e\u7684\u306a\u899a\u9192\u5ea6\u5411\u4e0a\u3084\u96c6\u4e2d\u529b\u5411\u4e0a\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u305d\u306e\u5f8c\u306e\u5168\u8eab\u7684\u306a\u526f\u4ea4\u611f\u795e\u7d4c\u512a\u4f4d\u5316\u3068\u6574\u5408\u3059\u308b\u73fe\u8c61\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u7dcf\u3058\u3066\u3001\u7de9\u6d88\u6cd5\u306f\u30db\u30eb\u30e2\u30f3\u30fb\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u306e\u30d0\u30e9\u30f3\u30b9\u3092\u6574\u3048\u3001**\u30b9\u30c8\u30ec\u30b9\u8efd\u6e1b\uff08\u4f4e\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\uff09<strong data-start=\"6876\" data-end=\"6881\">\u3068<\/strong>\u6c17\u5206\u9ad8\u63da\uff08\u9ad8\u30bb\u30ed\u30c8\u30cb\u30f3\/\u30c9\u30fc\u30d1\u30df\u30f3\u3001\u9ad8\u30aa\u30ad\u30b7\u30c8\u30b7\u30f3\uff09**\u3068\u3044\u3046\u5185\u5206\u6ccc\u5b66\u7684\u52b9\u679c\u3092\u3082\u305f\u3089\u3059\u4eee\u8aac\u304c\u7acb\u3066\u3089\u308c\u308b\u3002<\/p>\n<p data-start=\"6935\" data-end=\"6951\"><strong data-start=\"6935\" data-end=\"6949\">\u53c2\u8003\u6587\u732e\uff08\u4eee\u8aac7\uff09:<\/strong><\/p>\n<ul data-start=\"6952\" data-end=\"7252\">\n<li data-start=\"6952\" data-end=\"7252\">\n<p data-start=\"6954\" data-end=\"7252\"><em data-start=\"6954\" data-end=\"7033\">Massage increases oxytocin and reduces adrenocorticotropin hormone in humans.<\/em> Morhenn VB, Beavin LE, Zak PJ. 2012, Altern Ther Health Med. PubMed<br data-start=\"7146\" data-end=\"7149\" \/><em data-start=\"7149\" data-end=\"7252\">(Field\u3089\u306b\u3088\u308b\u7dcf\u8aac\u200b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5467308\/#:~:text=Cortisol%20levels%20that%20are%20often,have%20increased\" target=\"_blank\" rel=\"noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3082\u53c2\u7167\uff1a\u30de\u30c3\u30b5\u30fc\u30b8\u5f8c\u306b\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u30fb\u30ce\u30eb\u30a2\u30c9\u30ec\u30ca\u30ea\u30f3\u4f4e\u4e0b\u3001\u30bb\u30ed\u30c8\u30cb\u30f3\u30fb\u30c9\u30fc\u30d1\u30df\u30f3\u4e0a\u6607)<\/em><\/p>\n<\/li>\n<\/ul>\n<h2 data-start=\"7254\" data-end=\"7279\">\u4eee\u8aac8\uff1a\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306e\u52b9\u7387\u5316\u3068\u56de\u5fa9\u4fc3\u9032<\/h2>\n<p data-start=\"7280\" data-end=\"8128\"><strong data-start=\"7280\" data-end=\"7287\">\u5185\u5bb9\uff1a<\/strong> \u7de9\u6d88\u6cd5\u306b\u3088\u308b\u7b4b\u8089\u306e\u6df1\u3044\u5f1b\u7de9\u306f\u3001\u5c40\u6240\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u74b0\u5883\u3092\u6539\u5584\u3057\u3001\u7b4b\u306e\u56de\u5fa9\u3092\u4fc3\u9032\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u30de\u30c3\u30b5\u30fc\u30b8\u523a\u6fc0\u304c\u52a0\u308f\u308b\u3068\u7b4b\u7d44\u7e54\u3067\u306f<strong data-start=\"7353\" data-end=\"7371\">ATP\u7523\u751f\u3068\u5229\u7528\u306e\u52b9\u7387\u304c\u5909\u5316<\/strong>\u3057\u3046\u308b\u3002Crane\u3089\u306e\u7814\u7a76\u3067\u306f\u3001\u904b\u52d5\u5f8c\u306e\u7b4b\u8089\u306b10\u5206\u9593\u306e\u30de\u30c3\u30b5\u30fc\u30b8\u3092\u65bd\u3059\u3068\u3001\u7d30\u80de\u5185\u3067<strong data-start=\"7413\" data-end=\"7443\">\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306e\u53f8\u4ee4\u5854\u3067\u3042\u308bPGC-1\u03b1\u306e\u767a\u73fe\u304c\u4ea2\u9032<\/strong>\u3057\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6a5f\u80fd\u56de\u5fa9\u30b7\u30b0\u30ca\u30eb\u304c\u4fc3\u9032\u3055\u308c\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u200b<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22301554\/#:~:text=found%20that%20massage%20activated%20the,to%20skeletal%20muscle%20that%20has\" target=\"_blank\" rel=\"noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u3002\u540c\u6642\u306b\u708e\u75c7\u8a98\u5c0e\u7d4c\u8def\u3067\u3042\u308bNF-\u03baB\u306e\u6838\u79fb\u884c\u3084\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08TNF-\u03b1\u3001IL-6\uff09\u306e\u7523\u751f\u304c\u6291\u5236\u3055\u308c\u3001\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u30bf\u30f3\u30d1\u30afHSP27\u306e\u30ea\u30f3\u9178\u5316\u3082\u4f4e\u6e1b\u3057\u305f\u200b<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22301554\/#:~:text=found%20that%20massage%20activated%20the,to%20skeletal%20muscle%20that%20has\" target=\"_blank\" rel=\"noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u30de\u30c3\u30b5\u30fc\u30b8\u304c<strong data-start=\"7659\" data-end=\"7705\">\u7b4b\u7d30\u80de\u5185\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u7cfb\u3092\u6d3b\u6027\u5316\u3057\u3064\u3064\u3001\u904e\u5270\u306a\u708e\u75c7\u53cd\u5fdc\u306b\u3088\u308b\u30a8\u30cd\u30eb\u30ae\u30fc\u6d6a\u8cbb\u3092\u6291\u3048\u308b<\/strong>\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002\u200b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4393190\/#:~:text=2013%20%29,early%20phase%20might%20be%20related\" target=\"_blank\" rel=\"noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u307e\u305f\u3001\u52d5\u7269\u30e2\u30c7\u30eb\uff08\u30e9\u30c3\u30c8\uff09\u306e\u7814\u7a76\u3067\u3082\u3001\u904e\u5ea6\u306e\u904b\u52d5\u3067\u751f\u3058\u305f\u7b4b\u8089\u75db\u306b\u5bfe\u3057\u30de\u30cb\u30e5\u30a2\u30eb\u30bb\u30e9\u30d4\u30fc\u3092\u884c\u3046\u3068\u3001\u7b4b\u4e2d\u306e<strong data-start=\"7812\" data-end=\"7831\">\u4e73\u9178\u3001\u30de\u30ed\u30f3\u9178\u3001\u5206\u679d\u9396\u30a2\u30df\u30ce\u9178<\/strong>\u306a\u3069\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u95a2\u9023\u7269\u8cea\u306e\u52d5\u614b\u304c\u6709\u610f\u306b\u5909\u5316\u3057\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u547c\u5438\u56de\u8def\u306e\u57fa\u8cea\uff08\u30af\u30a8\u30f3\u9178\u56de\u8def\u4e2d\u9593\u4f53\u7b49\uff09\u306e\u5897\u52a0\u304c\u89b3\u5bdf\u3055\u308c\u3066\u3044\u308b\u200b<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4393190\/#:~:text=total%20of%20171%20metabolites%20were,metabolites%20associated%20with%20mitochondrial%20respiration\" target=\"_blank\" rel=\"noopener\">pmc.ncbi.nlm.nih.gov<\/a>\u3002\u3053\u308c\u306f\u7b4b\u7d44\u7e54\u3067\u306e<strong data-start=\"7947\" data-end=\"7959\">\u597d\u6c17\u7684\u4ee3\u8b1d\u306e\u4fc3\u9032<\/strong>\u3092\u610f\u5473\u3057\u3001\u75b2\u52b4\u56de\u5fa9\u306e\u52a0\u901f\u306b\u3064\u306a\u304c\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u3055\u3089\u306b\u3001\u7b4b\u304c\u5f1b\u7de9\u3059\u308b\u3053\u3068\u3067\u5c40\u6240\u8840\u6d41\u304c\u6539\u5584\u3057\u9178\u7d20\u30fb\u6804\u990a\u4f9b\u7d66\u304c\u5897\u5927\u3059\u308b\u305f\u3081\u3001<strong data-start=\"8019\" data-end=\"8039\">\u30a8\u30cd\u30eb\u30ae\u30fc\u7523\u751f\u306b\u5fc5\u8981\u306a\u57fa\u8cea\u306e\u4f9b\u7d66<\/strong>\u3082\u5411\u4e0a\u3059\u308b\u3002\u307e\u3068\u3081\u308b\u3068\u3001\u7de9\u6d88\u6cd5\u306f<strong data-start=\"8055\" data-end=\"8094\">\u7b4b\u7d44\u7e54\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u52b9\u7387\u3092\u9ad8\u3081\u3001\u708e\u75c7\u306a\u3069\u7121\u99c4\u306a\u30a8\u30cd\u30eb\u30ae\u30fc\u6d88\u8cbb\u3092\u6e1b\u3089\u3059<\/strong>\u3053\u3068\u3067\u3001\u7b4b\u306e\u75b2\u52b4\u56de\u5fa9\u3084\u640d\u50b7\u4fee\u5fa9\u3092\u751f\u5316\u5b66\u7684\u306b\u652f\u63f4\u3059\u308b\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u308b\u3002<\/p>\n<p data-start=\"8130\" data-end=\"8146\"><strong data-start=\"8130\" data-end=\"8144\">\u53c2\u8003\u6587\u732e\uff08\u4eee\u8aac8\uff09:<\/strong><\/p>\n<ul data-start=\"8147\" data-end=\"8619\" data-is-only-node=\"\">\n<li data-start=\"8147\" data-end=\"8395\">\n<p data-start=\"8149\" data-end=\"8395\"><em data-start=\"8149\" data-end=\"8238\">Massage therapy attenuates inflammatory signaling after exercise-induced muscle damage.<\/em> Crane JD, Ogborn DI, Cupido C, Melov S, Hubbard A, Bourgeois JM, Tarnopolsky MA. 2012, Sci Transl Med. PubMed<\/p>\n<\/li>\n<li data-start=\"8396\" data-end=\"8619\">\n<p data-start=\"8398\" data-end=\"8619\"><em data-start=\"8398\" data-end=\"8495\">Manual therapy ameliorates delayed-onset muscle soreness and alters muscle metabolites in rats.<\/em> Urakawa S, Takamoto K, Nakamura T, Sakai S, et al. 2015, Physiol Rep. PubMed<\/p>\n<\/li>\n<\/ul>\n<h2 data-start=\"61\" data-end=\"98\">\u4eee\u8aac9\uff1a\u81ea\u52d5\u53ce\u7e2e\u5f8c\u306e\u81ea\u539f\u6291\u5236\u30fb\u76ae\u8cea\u5185\u6291\u5236\u30fb\u7b4b\u30dd\u30f3\u30d7\u52b9\u679c\u306b\u3088\u308b\u5f1b\u7de9\u5897\u5927<\/h2>\n<ul>\n<li data-start=\"68\" data-end=\"346\">\n<p data-start=\"71\" data-end=\"116\"><strong data-start=\"71\" data-end=\"114\">\u30b4\u30eb\u30b8\u8171\u5668\u5b98\u3092\u4ecb\u3057\u305f\u81ea\u539f\u6291\u5236\uff08Autogenic Inhibition\uff09\u306e\u5f37\u5316<\/strong><\/p>\n<ul data-start=\"120\" data-end=\"346\">\n<li data-start=\"120\" data-end=\"178\">\n<p data-start=\"122\" data-end=\"178\">\u81ea\u767a\u7684\u7b49\u5c3a\u6027\u53ce\u7e2e\u306b\u3088\u3063\u3066\u8171\u90e8\u5f35\u529b\u304c\u9ad8\u307e\u308a\u3001Ib\u7dda\u7dad\uff08\u30b4\u30eb\u30b8\u8171\u5668\u5b98\uff09\u304c\u5f37\u304f\u6d3b\u6027\u5316\u2192\u03b1\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u6291\u5236\u304c\u5897\u5927\u3002<\/p>\n<\/li>\n<li data-start=\"182\" data-end=\"290\">\n<p data-start=\"184\" data-end=\"290\">Etnyre &amp; Abraham (1986) \u306f\u3001PNF\u306e\u201ccontract\u2013relax\u201d\u624b\u6280\u3067\u9759\u7684\u30b9\u30c8\u30ec\u30c3\u30c1\u306b\u6bd4\u3079H\u2011reflex\u304c\u5927\u5e45\u306b\u6291\u5236\u3055\u308c\u308b\u3053\u3068\u3092\u5831\u544a\u3010Etnyre &amp; Abraham 1986\u3011<\/p>\n<\/li>\n<li data-start=\"294\" data-end=\"346\">\n<p data-start=\"296\" data-end=\"346\">PubMed: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/2417817\/\" target=\"_new\" rel=\"noopener\" data-start=\"304\" data-end=\"344\">https:\/\/pubmed.ncbi.nlm.nih.gov\/2417817\/<\/a><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li data-start=\"348\" data-end=\"619\">\n<p data-start=\"351\" data-end=\"395\"><strong data-start=\"351\" data-end=\"393\">\u62ee\u6297\u7b4b\u53ce\u7e2e\u306b\u3088\u308b\u76f8\u53cd\u6291\u5236\uff08Reciprocal Inhibition\uff09\u306e\u4fc3\u9032<\/strong><\/p>\n<ul data-start=\"399\" data-end=\"619\">\n<li data-start=\"399\" data-end=\"458\">\n<p data-start=\"401\" data-end=\"458\">\u5bfe\u8c61\u7b4b\u306e\u53ce\u7e2e\u3068\u540c\u6642\u306b\u62ee\u6297\u7b4b\u3082\u52d5\u54e1\u2192Ia\u6c42\u5fc3\u6027\u5165\u529b\u304c\u5897\u5f37\u2192\u62ee\u6297\u7d4c\u8def\u3092\u4ecb\u3057\u5bfe\u8c61\u7b4b\u03b1\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u6291\u5236\u304c\u4e00\u5c64\u5f37\u307e\u308b\u3002<\/p>\n<\/li>\n<li data-start=\"462\" data-end=\"562\">\n<p data-start=\"464\" data-end=\"562\">Sharman et\u00a0al. (2006) \u306f\u3001PNF\u30b9\u30c8\u30ec\u30c3\u30c1\u306e\u300c\u77ed\u7e2e\u53ce\u7e2e\uff0b\u7b49\u5c3a\u6027\u53ce\u7e2e\u300d\u304c\u6700\u3082\u53ef\u52d5\u57df\u3092\u62e1\u5927\u3057\u3001\u5358\u306a\u308b\u81ea\u539f\u6291\u5236\u4ee5\u4e0a\u306e\u76f8\u53cd\u6291\u5236\u5bc4\u4e0e\u3092\u793a\u5506\u3010Sharman et\u00a0al. 2006\u3011<\/p>\n<\/li>\n<li data-start=\"566\" data-end=\"619\">\n<p data-start=\"568\" data-end=\"619\">PubMed: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17052131\/\" target=\"_new\" rel=\"noopener\" data-start=\"576\" data-end=\"617\">https:\/\/pubmed.ncbi.nlm.nih.gov\/17052131\/<\/a><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li data-start=\"621\" data-end=\"877\">\n<p data-start=\"624\" data-end=\"654\"><strong data-start=\"624\" data-end=\"652\">\u6a5f\u68b0\u7684\u30dd\u30f3\u30d7\u4f5c\u7528\u306e\u5897\u5927\u306b\u3088\u308b\u9593\u8cea\u6d41\u4f53\u52d5\u614b\u306e\u6d3b\u6027\u5316<\/strong><\/p>\n<ul data-start=\"658\" data-end=\"877\">\n<li data-start=\"658\" data-end=\"715\">\n<p data-start=\"660\" data-end=\"715\">\u81ea\u52d5\u53ce\u7e2e\uff0f\u5f1b\u7de9\u30b5\u30a4\u30af\u30eb\u304c\u4ed6\u52d5\u7684\u4f38\u5f35\u3088\u308a\u5927\u304d\u306a\u5727\u5909\u52d5\u3092\u751f\u307f\u3001\u9593\u8cea\u6db2\u30fb\u30ea\u30f3\u30d1\u6d41\u30fb\u5fae\u5c0f\u8840\u7ba1\u9084\u6d41\u3092\u3088\u308a\u5f37\u529b\u306b\u4fc3\u9032\u3002<\/p>\n<\/li>\n<li data-start=\"719\" data-end=\"820\">\n<p data-start=\"721\" data-end=\"820\">Duclay &amp; Martin (2005) \u306f\u3001\u81ea\u767a\u7684\u7b49\u5c3a\u6027\u30fb\u77ed\u7e2e\u6027\u30fb\u4f38\u5f35\u6027\u53ce\u7e2e\u6642\u306eV\u2011wave\u5fdc\u7b54\u304c\u7dad\u6301\u3055\u308c\u3001\u6a5f\u68b0\u523a\u6fc0\u3068\u795e\u7d4c\u2013\u7b4b\u5fdc\u7b54\u306e\u6700\u9069\u5316\u3092\u793a\u5506\u3010Duclay &amp; Martin 2005\u3011<\/p>\n<\/li>\n<li data-start=\"824\" data-end=\"877\">\n<p data-start=\"826\" data-end=\"877\">PubMed: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16049144\/\" target=\"_new\" rel=\"noopener\" data-start=\"834\" data-end=\"875\">https:\/\/pubmed.ncbi.nlm.nih.gov\/16049144\/<\/a><\/p>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 data-start=\"79\" data-end=\"113\">\u4eee\u8aac10\uff1a\u9593\u8ceaCa\u00b2\u207a\u6fc3\u5ea6\u5909\u52d5\u306b\u3088\u308b\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u7db2\u306e\u518d\u69cb\u7bc9<\/h2>\n<ul data-start=\"114\" data-end=\"604\">\n<li data-start=\"114\" data-end=\"270\">\n<p data-start=\"116\" data-end=\"270\"><strong data-start=\"116\" data-end=\"122\">\u6a5f\u69cb<\/strong>\uff1a\u7de9\u6d88\u6cd5\u306e\u5727\u523a\u6fc0\u30fb\u81ea\u52d5\u53ce\u7e2e\u30b5\u30a4\u30af\u30eb\u306b\u3088\u308a\u3001\u7b4b\u7d30\u80de\u3084\u5468\u56f2\u7dda\u7dad\u82bd\u7d30\u80de\u304b\u3089\u4e00\u904e\u7684\u306b\u653e\u51fa\u3055\u308c\u305fCa\u00b2\u207a\u304c\u9593\u8cea\u306b\u62e1\u6563\u3057\u3001HA\u9396\u9593\u306e\u6c34\u7d20\u7d50\u5408\u3084\u9759\u96fb\u7684\u76f8\u4e92\u4f5c\u7528\u3092\u4fee\u98fe\u3057\u307e\u3059\u3002\u7279\u306bCa\u00b2\u207a\u6fc3\u5ea6\u304c\u6570mM\u7a0b\u5ea6\u307e\u3067\u4e0a\u6607\u3059\u308b\u3068\u3001HA\u5206\u5b50\u540c\u58eb\u306e\u9023\u7d50\u304c\u7de9\u307f\u3001**\u7c98\u5ea6\u304c\u6025\u6fc0\u306b\u4f4e\u4e0b\uff08\u30c1\u30ad\u30bd\u30c8\u30ed\u30d4\u30fc\u6027\uff09**\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<\/li>\n<li data-start=\"271\" data-end=\"501\">\n<p data-start=\"273\" data-end=\"285\"><strong data-start=\"273\" data-end=\"282\">\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong>\uff1a<\/p>\n<ul data-start=\"288\" data-end=\"501\">\n<li data-start=\"288\" data-end=\"395\">\n<p data-start=\"290\" data-end=\"395\">0.1% HA\u6eb6\u6db2\u4e2d\u3067CaCl\u2082\u6fc3\u5ea63\u00a0mM\u4ee5\u4e0a\u306b\u3059\u308b\u3068\u7c98\u5ea6\u304c\u5287\u7684\u306b\u4f4e\u4e0b\u3059\u308b\uff083\u00a0mM CaCl\u2082\u3067\u9855\u8457\u306a\u7c98\u5ea6\u6e1b\u5c11\uff09\u200b<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.macromol.0c02242?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noopener\">ACS Publications<\/a>\u3002<\/p>\n<\/li>\n<li data-start=\"398\" data-end=\"501\">\n<p data-start=\"400\" data-end=\"501\">\u540c\u69d8\u306b\u3001Ca\u00b2\u207a\u6dfb\u52a0\u306fHA\u306e\u4e8c\u6b21\u69cb\u9020\u3092\u4e0d\u5b89\u5b9a\u5316\u3057\u3001\u5206\u5b50\u306e\u5e73\u9762\u7684\u5c55\u958b\u3092\u4fc3\u3057\u3066\u7c98\u5ea6\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u200b<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0002962915362741?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noopener\">\u30b5\u30a4\u30a8\u30f3\u30b9\u30c0\u30a4\u30ec\u30af\u30c8<\/a>\u3002<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li data-start=\"502\" data-end=\"604\">\n<p data-start=\"504\" data-end=\"604\"><strong data-start=\"504\" data-end=\"513\">\u81e8\u5e8a\u7684\u610f\u7fa9<\/strong>\uff1a\u7de9\u6d88\u6cd5\u3067\u52a0\u5727\u30fb\u4f38\u7e2e\u3092\u7e70\u308a\u8fd4\u3059\u3053\u3068\u3067\u751f\u3058\u308b\u5c40\u6240Ca\u00b2\u207a\u6fc3\u5ea6\u306e\u5909\u52d5\u304c\u3001HA\u306e\u30be\u30eb\u2013\u30b2\u30eb\u8ee2\u79fb\u3092\u3055\u3089\u306b\u4fc3\u9032\u3057\u3001\u7b4b\u819c\u9593\u306e\u6ed1\u8d70\u6027\u5411\u4e0a\u304a\u3088\u3073\u8d85\u97f3\u6ce2\u30a8\u30b3\u30fc\u4e0a\u306e\u4f4e\u30a8\u30b3\u30fc\u50cf\u5316\u306b\u5bc4\u4e0e\u3059\u308b\u3068\u63a8\u5bdf\u3055\u308c\u307e\u3059\u3002<\/p>\n<\/li>\n<\/ul>\n<h2 data-start=\"611\" data-end=\"641\">\u4eee\u8aac11\uff1a\u30a4\u30aa\u30f3\u5f37\u5ea6\u5909\u5316\u306b\u3088\u308b\u9593\u8cea\u6c34\u5206\u52d5\u614b\u306e\u5236\u5fa1<\/h2>\n<ul data-start=\"642\" data-end=\"1040\">\n<li data-start=\"642\" data-end=\"812\">\n<p data-start=\"644\" data-end=\"812\"><strong data-start=\"644\" data-end=\"650\">\u6a5f\u69cb<\/strong>\uff1a\u5727\u8feb\u2013\u89e3\u653e\u30b5\u30a4\u30af\u30eb\u306b\u3088\u3063\u3066\u9593\u8cea\u6db2\u304c\u7d5e\u308a\u51fa\u3055\u308c\u308b\u3068\u3001\u5c40\u6240\u306eNa\u207a\u3084Ca\u00b2\u207a\u3092\u542b\u3080\u96fb\u89e3\u8cea\u6fc3\u5ea6\u304c\u4e00\u6642\u7684\u306b\u4e0a\u6607\u3057\u3001\u89e3\u653e\u6642\u306e\u518d\u704c\u6d41\u3067\u6fc3\u5ea6\u304c\u5e0c\u91c8\u3055\u308c\u307e\u3059\u3002\u3053\u306e<strong data-start=\"724\" data-end=\"736\">\u30a4\u30aa\u30f3\u5f37\u5ea6\u306e\u632f\u52d5<\/strong>\u304c\u30aa\u30b9\u30e2\u30c6\u30a3\u30c3\u30af\u30c9\u30e9\u30a4\u30d0\u30fc\u3068\u3057\u3066\u6c34\u5206\u79fb\u52d5\u3092\u4fc3\u3057\u3001HA\u6eb6\u6db2\u306e\u7c98\u5ea6\u4f4e\u4e0b\u2192\u518d\u7c98\u5ea6\u5316\u3092\u7e70\u308a\u8fd4\u3059\u3053\u3068\u3067\u7d44\u7e54\u306e\u30be\u30eb\u2013\u30b2\u30eb\u72b6\u614b\u30b9\u30a4\u30c3\u30c1\u3092\u6d3b\u6027\u5316\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<\/li>\n<li data-start=\"813\" data-end=\"953\">\n<p data-start=\"815\" data-end=\"827\"><strong data-start=\"815\" data-end=\"824\">\u30a8\u30d3\u30c7\u30f3\u30b9<\/strong>\uff1a<\/p>\n<ul data-start=\"830\" data-end=\"953\">\n<li data-start=\"830\" data-end=\"953\">\n<p data-start=\"832\" data-end=\"953\">NaCl\u304a\u3088\u3073CaCl\u2082\u306e\u6dfb\u52a0\u306f\u3044\u305a\u308c\u3082HA\u6eb6\u6db2\u306e\u4f4e\u526a\u65ad\u7c98\u5ea6\u3092\u6e1b\u5c11\u3055\u305b\u308b\u304c\u3001\u660e\u78ba\u306a\u30a4\u30aa\u30f3\u30d6\u30ea\u30c3\u30b8\u5f62\u6210\u306f\u89b3\u5bdf\u3055\u308c\u306a\u3044\uff08Ca\u00b2\u207a\u3067\u3082\u30a4\u30aa\u30f3\u5f37\u5ea6\u52b9\u679c\u304c\u4e3b\uff09\u200b<a href=\"https:\/\/complexfluids.umd.edu\/papers\/166_2021.pdf?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noopener\">Complex Fluids<\/a>\u3002<\/p>\n<\/li>\n<\/ul>\n<\/li>\n<li data-start=\"954\" data-end=\"1040\">\n<p data-start=\"956\" data-end=\"1040\"><strong data-start=\"956\" data-end=\"965\">\u81e8\u5e8a\u7684\u610f\u7fa9<\/strong>\uff1a\u3053\u306e\u6a5f\u69cb\u306b\u3088\u308a\u3001\u7de9\u6d88\u6cd5\u306e\u7269\u7406\u7684\u30dd\u30f3\u30d7\u4f5c\u7528\u3068\u76f8\u307e\u3063\u3066\u3001<strong data-start=\"992\" data-end=\"1029\">\u9593\u8cea\u306e\u6c34\u548c\u30fb\u8131\u6c34\u304c\u30bf\u30a4\u30e0\u30ea\u30fc\u306b\u7e70\u308a\u8fd4\u3055\u308c\u3001HA\u306e\u6d41\u52d5\u6027\u5909\u5316\u304c\u6700\u5927\u5316<\/strong>\u3055\u308c\u308b\u3068\u63a8\u6e2c\u3055\u308c\u307e\u3059\u3002<\/p>\n<\/li>\n<\/ul>\n<hr data-start=\"1042\" data-end=\"1045\" \/>\n<pre data-start=\"1047\" data-end=\"1060\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/pre>\n<ol data-start=\"1061\" data-end=\"1877\">\n<li data-start=\"1061\" data-end=\"1309\">\n<p data-start=\"1064\" data-end=\"1309\"><strong data-start=\"1064\" data-end=\"1150\">Strong Reduction of the Chain Rigidity of Hyaluronan by Selective Divalent Cations<\/strong><br data-start=\"1150\" data-end=\"1153\" \/><em data-start=\"1156\" data-end=\"1173\">ACS Macro Lett.<\/em> 2020;9(9):1207\u20131213.<br data-start=\"1194\" data-end=\"1197\" \/>\u201cAbove 3\u00a0mM CaCl\u2082, viscosity of 0.1% HA solutions sharply decreases.\u201d <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.macromol.0c02242?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noopener\">ACS Publications<\/a><\/p>\n<\/li>\n<li data-start=\"1311\" data-end=\"1557\">\n<p data-start=\"1314\" data-end=\"1557\"><strong data-start=\"1314\" data-end=\"1386\">Calcium Destabilizes and Causes Conformational Changes in Hyaluronan<\/strong><br data-start=\"1386\" data-end=\"1389\" \/><em data-start=\"1392\" data-end=\"1411\">Carbohydr. Polym.<\/em> 2016;153:341\u2013348.<br data-start=\"1429\" data-end=\"1432\" \/>\u201cIncreasing CaCl\u2082 lowers HA viscosity via destabilization of secondary structure.\u201d <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0002962915362741?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noopener\">\u30b5\u30a4\u30a8\u30f3\u30b9\u30c0\u30a4\u30ec\u30af\u30c8<\/a><\/p>\n<\/li>\n<li data-start=\"1559\" data-end=\"1877\">\n<p data-start=\"1562\" data-end=\"1877\"><strong data-start=\"1562\" data-end=\"1662\">Comparison of the Rheological Properties of Cartilage Glycosaminoglycans and Soft Tissue Fillers<\/strong><br data-start=\"1662\" data-end=\"1665\" \/><em data-start=\"1668\" data-end=\"1685\">Dermatol. Surg.<\/em> 2010;36 Suppl 3:1859\u20131865.<br data-start=\"1712\" data-end=\"1715\" \/>\u201cMonovalent (NaCl) and divalent (CaCl\u2082) salts reduce the low\u2010shear viscosity of HA solutions without phase separation.\u201d <a href=\"https:\/\/complexfluids.umd.edu\/papers\/166_2021.pdf?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noopener\">Complex Fluids<\/a><\/p>\n<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u7de9\u6d88\u6cd5\u306e\u7d44\u7e54\u30ec\u30d9\u30eb\u3067\u306e\u4f5c\u7528\u306b\u95a2\u3059\u308b\u591a\u89d2\u7684\u4eee\u8aac \u305f\u3060\u3044\u307e\u88fd\u4f5c\u4e2d\u3067\u3059\u3002 \u4eee\u8aac1\uff1a\u30d2\u30a2\u30eb\u30ed\u30f3\u9178\u7c98\u5ea6\u306e\u4f4e\u4e0b\u3068\u7b4b\u819c\u6ed1\u8d70\u6027\u306e\u5411\u4e0a \u5185\u5bb9\uff1a \u7de9\u6d88\u6cd5\u306e1cm\u00b2\u7403\u72b6\u5668\u5177\u306b\u3088\u308b500gf\u306e\u5727\u523a\u6fc0\u3068\u5f80\u5fa9\u52d5\u4f5c\uff084\u79d2\/\u5f80\u5fa9\uff09\u306f\u3001\u7b4b\u819c\u306e\u758e\u6027\u7d50\u5408\u7d44\u7e54 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-2467","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.kanshoho.com\/jp\/wp-json\/wp\/v2\/pages\/2467","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.kanshoho.com\/jp\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.kanshoho.com\/jp\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.kanshoho.com\/jp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.kanshoho.com\/jp\/wp-json\/wp\/v2\/comments?post=2467"}],"version-history":[{"count":28,"href":"https:\/\/www.kanshoho.com\/jp\/wp-json\/wp\/v2\/pages\/2467\/revisions"}],"predecessor-version":[{"id":2497,"href":"https:\/\/www.kanshoho.com\/jp\/wp-json\/wp\/v2\/pages\/2467\/revisions\/2497"}],"wp:attachment":[{"href":"https:\/\/www.kanshoho.com\/jp\/wp-json\/wp\/v2\/media?parent=2467"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}